Patient safety

22.07.20

University of Oxford coronavirus vaccine begins next phase of trials

Researchers at the University of Oxford have begun recruiting for the next phase in human trials of a coronavirus vaccine in human volunteers.

After the phase I trial in healthy adult volunteers began in April, with more than 1,000 immunisations having been completed and the follow-ups currently ongoing, the researchers are now looking to recruit ahead of the phase II and phase III parts of the vaccine study.

The next study will enrol up to 10,260 adults and children and will involve a number of partner institutions across the country.

For the phase II part of the study, it will involve expanding the age range of people the vaccine is assessed in to include a small number of older adults and children:

  • Aged 56-69
  • Aged over 70
  • Aged between 5-12 years

Researchers will be assessing the immune response to the vaccine in people of different ages, in order to discover if there is variation in how well the immune system responds in older people or children.

The phase III part of the study involves assessing how the vaccine works in a large number of people over the age of 18. This group will assess how well the vaccine works to prevent people from becoming infected and unwell with Covid-19.

Adult participants in both the Phase II and Phase III groups will be randomised and receive one or two doses of either the ChAdOx1 nCoV-19 vaccine or a licensed vaccine (MenACWY) that will be used as a ‘control’ for comparison.

The ChAdOx1 nCoV-19 vaccine is made from a virus (ChAdOx1) which is a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees, which has been genetically changed so that it is impossible for it to replicate in humans.

Professor Andrew Pollard, Head of the Oxford Vaccine Group, said: 'The clinical studies are progressing very well and we are now initiating studies to evaluate how well the vaccine induces immune responses in older adults, and to test whether it can provide protection in the wider population.

“We are very grateful to the huge support of the trial volunteers in helping test whether this new vaccine could protect humans against the pandemic coronavirus.'

Sarah Gilbert, Professor of Vaccinology at the Jenner Institute, said: 'The Covid-19 vaccine trial team have been working hard on assessing the safety and immunogenicity of ChAdOx1 nCoV-19, and preparing to assess vaccine efficacy.

“We have had a lot of interest already from people over the age of 55 years who were not eligible to take part in the phase I study, and we will now be able to include older age groups to continue the vaccine assessment. We will also be including more study sites, in different parts of the country.”

The study aims to assess how well people across a broad range of ages could be protected from Covid-19 with this new ChAdOx1 nCoV-19 vaccine. It will also provide valuable information on safety aspects of the vaccine and its ability to generate good immune responses against the virus.

Comments

There are no comments. Why not be the first?

Add your comment

 

national health executive tv

more videos >

latest healthcare news

BMA calls for further investment, innovation into mental health

13/08/2020BMA calls for further investment, innovation into mental health

As coronavirus and the restrictions and measures which were taken to counteract it put an increased strain on people’s mental health, the B... more >
Work underway on £14.5m specialist CAMHS unit in Leeds

13/08/2020Work underway on £14.5m specialist CAMHS unit in Leeds

Work on a new state-of-the-art £14.5m Child and Adolescent Mental Health Service (CAMHS) unit, being built in partnerships between Leeds Co... more >
Consistent UK-wide methodology set to record Covid-19 deaths

13/08/2020Consistent UK-wide methodology set to record Covid-19 deaths

Following a review by Public Health England (PHE) into the methodology used to calculate the number of Covid-19 deaths in the UK, a new single, c... more >

editor's comment

26/06/2020Adapting and Innovating

Matt Roberts, National Health Executive Editorial Lead. NHE May/June 2020 Edition We’ve been through so much as a health sector and a society in recent months with coronavirus and nothing can take away from the loss and difficulties that we’ve faced but it vital we also don’t disregard the amazing efforts we’v... read more >

last word

Haseeb Ahmad: ‘We all have a role to play in getting innovations quicker’

Haseeb Ahmad: ‘We all have a role to play in getting innovations quicker’

Haseeb Ahmad, president of the Association of the British Pharmaceutical Industry (ABPI), sits down with National Health Executive as part of our Last Word Q&A series. Would you talk us th... more > more last word articles >

the scalpel's daily blog

Calling the NHS a ‘Covid-only service’ is untrue, unfair and potentially dangerous

12/08/2020Calling the NHS a ‘Covid-only service’ is untrue, unfair and potentially dangerous

Chris Hopson, Chief Executive, NHS Providers Last week the NHS was widely described as providing a ‘Covid-19 only’ service for much of the last few months. Frontline NHS trust leaders are frustrated and disappointed at this description as it is untrue, unfair and potentially dangerous. It is untrue because local hospital ... more >
read more blog posts from 'the scalpel' >

comment

NHS England dementia director prescribes rugby for mental health and dementia patients

23/09/2019NHS England dementia director prescribes rugby for mental health and dementia patients

Reason to celebrate as NHS says watching rugby can be good for your mental health and wellbeing. As the best rugby players in the world repr... more >
Peter Kyle MP: It’s time to say thank you this Public Service Day

21/06/2019Peter Kyle MP: It’s time to say thank you this Public Service Day

Taking time to say thank you is one of the hidden pillars of a society. Being on the receiving end of some “thanks” can make communit... more >
Nurses named as least-appreciated public sector workers

13/06/2019Nurses named as least-appreciated public sector workers

Nurses have been named as the most under-appreciated public sector professionals as new research reveals how shockingly under-vauled our NHS, edu... more >
Creating the Cardigan integrated care centre

10/06/2019Creating the Cardigan integrated care centre

Peter Skitt, county director and commissioner for Ceredigion Hywel Dda University Health Board, looks ahead to the new integrated care centre bei... more >

interviews

Matt Hancock says GP recruitment is on the rise to support ‘bedrock of the NHS’

24/10/2019Matt Hancock says GP recruitment is on the rise to support ‘bedrock of the NHS’

Today, speaking at the Royal College of General Practitioners (RCGP) annual conference, Matt Hancock highlighted what he believes to be the three... more >
NHS dreams come true for Teesside domestic

17/09/2019NHS dreams come true for Teesside domestic

Over 20 years ago, a Teesside hospital cleaner put down her mop and took steps towards her midwifery dreams. Lisa Payne has been delivering ... more >
How can winter pressures be dealt with? Introduce a National Social Care Service, RCP president suggests

24/10/2018How can winter pressures be dealt with? Introduce a National Social Care Service, RCP president suggests

A dedicated national social care service could be a potential solution to surging demand burdening acute health providers over the winter months,... more >
RCP president on new Liverpool college building: ‘This will be a hub for clinicians in the north’

24/10/2018RCP president on new Liverpool college building: ‘This will be a hub for clinicians in the north’

The president of the Royal College of Physicians (RCP) has told NHE that the college’s new headquarters based in Liverpool will become a hu... more >

health service focus

View all News