AstraZeneca vaccine

Reason for blood clots caused by AstraZeneca vaccine unveiled

A team of scientists from Cardiff University have worked alongside Arizona State University and AstraZeneca to understand why the vaccine is causing blood clots in some of those who have had the jab.

A small number of people have developed Thrombosis with vaccine-induced immune thrombocytopenia (VITT) after receiving the vaccine which causes the formation of blood clots. The life- threatening condition has also formed in a number of those who have received the Johnson & Johnson vaccine.

Scientists have discovered that a protein found in blood, is attracted to a key component within the vaccines. They believe that this starts a chain reaction with the immune system causing the blood clots to form.

The UK’s medicines safety regulator has revealed that there has been 242 clot cases and 49 deaths since May.

The cases meant that the AstraZeneca vaccine was not offered to anyone under the age of 40 despite 28.5 million doses already being administered to those over forty.

Professor Alan Parker, a researcher at Cardiff University said: "The adenovirus has an extremely negative surface, and platelet factor four is extremely positive and the two things fit together quite well.

“We've been able to prove the link between the key smoking guns of adenoviruses and platelet factor four.

"What we have is the trigger, but there's a lot of steps that have to happen next."

Dr Will Lester, a consultant haematologist, said: "This is a very detailed scientific study from experts in the field and provides further pieces to a jigsaw of understanding vaccine induced thrombocytopenia and thrombosis.

"The authors reasonably speculate that one might be able to modify future adenoviral based vaccines to avoid this unwanted rare untoward effect.

"Many questions still remain unanswered; including whether some people may be more susceptible than others and why the thrombosis is most commonly in the veins of the brain and liver, but this may come with time and further research."

NHE Sept/Oct 21

NHE Sept/Oct 21

Improving care for long-term conditions

Join us in our September/October edition of National Health Executive, as we explore a range of topics impacting and improving the care that we can deliver to patients, the facilities within which we deliver them, and the opportunities in the digital space to accent and evolve our care capabilities


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National Health Executive Presents

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The integration of new technology, such as using virtual outpatient appointments instead of face-to-face reviews of patients in the hospital. Adapting the ways in which our NHS workers serve people has been critical in continuing to provide high-quality treatment, a positive patient experience and preventing Covid-19 transmission during the pandemic. Our healthcare sector has the potential to transform the way we continue to provide essential services while also improving patient care. But how easy is the integration of these innovations into routine NHS practice?

On the 28th of October, at the NHE365 Virtual Hospitals & Technology Enabled Care online event, we will be discussing patient flow and experience, reducing waiting times, reducing the patient backlog and increasing technology adoption. Will you be attending? 

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