Clinical research

Clinical Trials Alliance launches in North-West London

Imperial College Healthcare NHS Trust has become a partner in a new collaboration between clinical trial teams in North-West London, which launched yesterday.

The Clinical Trials Alliance aims to improve access to and the quality of clinical research in the region. Clinical research facilities (CRFs), primary care networks (PCNs), and the NIHR Clinical Research Network (CRN) in North-West London, including the CRFs at Imperial College Healthcare, have all joined the alliance, which will be dedicated to delivering co-ordinated clinical trials.

This will also use existing, purpose-designed facilities to deliver both early and late-phase trials. During the early stages of the Covid-19 pandemic, clinical research teams across North-West London joined together to respond collaboratively to the research needed.

The teams co-ordinated across the different facilities, meaning that research studies could be shared more effectively and appropriately, resulting in evidence that could inform national guidelines and policy more quickly. 

Dr Bob Klaber, Director of Strategy, Research and Innovation at Imperial College Health, spoke at the launch event and said: “It is great to see a positive collaboration such as this emerging from the response to the Covid-19 pandemic, which has been one of the greatest challenges the NHS has ever faced.

"By bringing together North-West London’s collective research experience and resource, we can be far more effective in bringing innovations and cutting-edge treatments to patients more quickly.” 

The approach worked so well in response to the pandemic, that teams from across the clinical research networks, the universities, and NHS organisations - which host the clinical research facilities - decided to formalise the arrangement and improve access to clinical trial resources for future research. 

The alliance will be focussed on industry funded (e.g. pharmaceutical companies) and publicly funded research trials (e.g. university-led or government funded research) and has an impressive recruitment record, meaning evidence can be strengthened by larger participant samples. 

Imperial College Healthcare has a number of clinical research facilities, including the NIHR Imperial Clinical Research Facility (CRF) on the Hammersmith Hospital campus, which played an integral role in research to develop a Covid-19 vaccine, and a children’s CRF at St Mary’s Hospital.

In response to the pandemic, the CRF - in collaboration with the other clinical trial teams in North-West London - paused140 existing studies across a variety of therapy areas to focus exclusively on delivering trials for candidate Covid-19 vaccines.

In April 2020, the CRF became one of the first recruiting centres that the Oxford Vaccine Group approached to help deliver their study, COV001. At its peak, the CRF was running three vaccine trials simultaneously at Hammersmith Hospital and a further vaccine trial at Charing Cross Hospital.

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