Clinical trial

Early clinical trial results show promise for Alzheimer’s treatment

Patients could be set to benefit from a breakthrough in dementia care after a clinical trial reported promising initial results for a treatment that alters the course of Alzheimer’s disease.

For the research, a team from University College London Hospitals NHS Foundation Trust (UCLH) investigated the efficacy of a treatment known as ALN-APP, a type of gene silencing therapy called RNA interference.

Researchers hope that this type of treatment can inhibit the production of amyloid proteins and therefore lead to the prevention of Alzheimer’s disease.

After enrolling 20 patients with early-onset Alzheimer's disease – the leading cause of dementia in young people – researchers found that single doses of ALN-APP were well tolerated and demonstrated significant and sustained reductions in specific amyloid molecules.

                                                                          Video credit: Canva

Consultant neurologist at UCLH’s national hospital for neurology and neurosurgery, Dr Catherine Mummery, is one of eight investigators worldwide for the trial, and the only one based in the UK.

The news comes shortly after results from the clinical trial studying the treatment, donanemab, were announced at the Alzheimer's Association International Conference, which revealed that the drug was able to delay deterioration in some patients by 35%.

Click here to find out more.

Image credit: iStock

NHE September/October 2023

NHE September/October 2023

Empowering the next generation to lead the way in hard-to-treat cancers.

The September/October 2023 edition of NHE brings you expert comment and analysis on a range of key health sector topics, from digital transformation to navigating post-pandemic challenges.

Videos...

View all videos
National Health Executive Presents

National Health Executive Presents

NHE365 Virtual Events

NHE has created a full calendar of events to address the most important issues that influence the delivery of healthcare services. Over 365 days you'll have the opportunity to hear from a range of highly motivating, informative and inspirational speakers. These speakers will equip you with the knowledge and unique insight to enable you to overcome the challenges that you face.

National Health Executive Podcast

Ep. 36
How interoperability can support the NHS's core goals
with Ed Platt

In episode 36 of the National Health Executive podcast, we were joined by Omnicell’s UK professional services director, Ed Platt, to discuss interoperability in the NHS, practical examples of where it can be leveraged best, the importance of the health service's digital transformation journey and more.

More articles...

View all