Two women either side of a door

Long covid linked to increased risk of abnormal blood clotting

A new study has revealed that people suffering from long Covid are at an increased risk of abnormal blood clotting.

The study was conducted by University College London Hospitals NHS Foundation Trust (UCLH) in conjunction with University College London and offers new insight into the potential mechanisms behind the long-term effects of Covid.

Given long Covid’s status as an emerging condition, much of its biological base is still yet unknown, with this research providing new insight.

“By definition, this syndrome occurs when one experiences Covid-related symptoms long after the onset of infection that we can't attribute to any other cause or diagnosis,” explained study author Dr Nithya Prasannan, of the Department of Haematology at UCLH. “This study offers us laboratory and clinical evidence to begin to understand why some people experience long Covid symptoms.”

A team led by UCLH’s Dr Melissa Heightman assessed people in an outpatient post-Covid clinic between July 2020 and May 2021.

Researchers measured abnormal blood clotting markers by assessing the relative levels of two proteins in the body. The researchers then analysed the ratio of Von Willebrand factor (VWF), which is important in blood clotting, to ADAMTS13, a protein that cuts VWF to prevent it from clogging blood vessels.

If the ratio of VWF significantly outweighed ADAMTS13 in the bloodstream, scientists characterised patients as being in a pro-thrombotic state, meaning they could face a greater risk of developing blood clots.

Patients also completed exercise tests, such as repeatedly going from a standing position to a sitting position while wearing oxygen monitors.

Researchers measured the patient’s oxygen levels before and after exercise to measure their lactate levels. Patients who showed a significant decrease in oxygen levels while exercising or a rise in lactate afterwards were said to demonstrate an impaired exercise capacity.

Patients with raised levels of blood clotting markers were also four times more likely to have an impaired exercise capacity.

More information on the study can be found here.

NHE May/June 22

NHE May/June 22

Developing a high-quality NHS estate

The new edition of NHE’s e-magazine highlights the latest in cyber security, pharmaceuticals, NHS workforce, NHS Estates, driving innovation in procurement and more with articles from the likes of Brendan Griffin-Ryan, Senior Category Manager, Estates & Facilities, NHS SBS (pg79), West London NHS Trust and Health Education England.

Videos...

View all videos
National Health Executive Presents

National Health Executive Presents

NHE365 Virtual Events

NHE has created a full calendar of events to address the most important issues that influence the delivery of healthcare services. Over 365 days you'll have the opportunity to hear from a range of highly motivating, informative and inspirational speakers. These speakers will equip you with the knowledge and unique insight to enable you to overcome the challenges that you face.

Finger on the Pulse

Ep 14. Health messaging is a science, Professor Craig Jackson

On Episode 14 of NHE's Finger on the Pulse podcast, we're joined by Professor Craig Jackson, Professor of Occupational Health Psychology
Birmingham City University to discuss the coronavirus pandemic, the health messaging around it and how those in power have missed a trick by overlooking the key role of psychology in informing the public of restrictions, measures and the ever-changing situation

More articles...

View all