New NICE migraine recommendation to benefit thousands

Thousands of NHS patients are set to benefit from a new treatment for acute migraine as the National Institute for Health and Care Excellence (NICE) recommends rimegepant for adults.

In final draft guidance, NICE has recommended rimegepant – otherwise known as Pfizer’s Vydura – for adults who have tried at least two triptans, but did not work.

The treatment is also recommended for adults who either cannot take triptans or they were not tolerated – this is the same for those who have unsuccessfully tried nonsteroidal anti-inflammatory drugs and paracetamol.

It is expected to benefit around 13,000 people once it is available on the NHS.

The medicine works by blocking the release of a protein called calcitonin gene-related peptide around the brain.

Clinical trial evidence showed rimegepant had a higher likelihood of reducing pain at two hours than a placebo.

Director of medicines evaluation at NICE, Helen Knight, said: “This is the first and only NICE-recommended medicine that can help alleviate the misery of acute migraines, and may be considered a step-change in treatment.”

She continued: “Migraine is a condition described in comments to NICE from carers and people with migraine as an invisible disability that affects all aspects of life including work, education, finances, mental health, social activities, and family.”

Final guidance is expected to be published in October for rimegepant.

Image credit: iStock

Website cover

NHE May/June 2024

Join the conversation shaping the future of healthcare.

Click below to read more!

More articles...

View all
Online Conference


2024 Online Conferences

In partnership with our community of health sector leaders responsible for delivering the UK's health strategy across the NHS and the wider health sector, we’ve devised a collaborative calendar of conferences and events for industry leaders to listen, learn and collaborate through engaging and immersive conversation. 

All our conferences are CPD accredited, which means you can gain points to advance your career by attending our online conferences. Also, the contents are available on demand so you can re-watch at your convenience.

National Health Executive Podcast

Listen to industry leaders on everything within healthcare

Whether it's the latest advancements in medical technology, healthcare policies, patient care innovations, or the challenges facing healthcare providers, we cover it all.


Join us as we engage with top healthcare professionals, industry leaders, and policy experts to bring you insightful conversations that matter.