Patient safety

09.01.20

University study could improve brain tumour precision medicine

The University of Bristol has today (Jan 9) revealed new research on brain tumours that could improve patient diagnosis and treatment options as part of a precision medicine approach.

The Brain Tumour Research Centre at the University of Bristol has collaborated with the Centre for Cancer Research and Cell Biology (CCRCB) at Queen’s University Belfast to investigate the genetics of brain tumours. Research from the study partnership was published in the Journal of Oncology.

The research involved extracting DNA from the brain tumours of 41 patients and characterising any changes or mutations. Results were recorded for different types of tumours both before and after treatment.

Mutations that are particular to different types of tumour were highlighted in the research, enabling the use of precision medicine, tailored to the specific DNA mutations in their tumour.

Existing licensed drugs used as combination therapies to target specific mutations were also listed in the new study. However, to ensure patient safety, any new combination therapies would first need to be tested in clinical trials before they would become available to patients.

Findings from the study give hope of developing new, more effective targeted treatments. Part of the research also followed mutations developed during brain cancer, presenting opportunities for new therapy options to be given as the cancer progresses and help to extend patient survival.

Dr Kathreena Kurian, Associate Professor in Brain Tumour Research at the University of Bristol, who led the research, said:

"New treatments are urgently needed for this incurable and devastating disease.  This approach should improve patient outcomes and save on prescribing medicines to patients that won’t benefit from them, thereby reducing patient exposure to toxic chemicals from chemotherapy, as well as saving the NHS money."

Brain tumours are the leading cause of cancer deaths in children and adults under the age of 40, with 16,000 people in the UK diagnosed with a brain tumour each year.

The work was supported by funding from Brain Tumour Bank and Research FundSouthmead Hospital Charity at North Bristol NHS Trust, University of Bristol  Development and Alumni Relations Office (DARO) and  Brainwaves Northern Ireland (NI).  Ethical approval for the study was given by BRAIN UK.

 

Photo: University of Bristol

Comments

There are no comments. Why not be the first?

Add your comment

 

national health executive tv

more videos >

latest healthcare news

Temporary registration granted to 11,800 doctors by GMC

27/03/2020Temporary registration granted to 11,800 doctors by GMC

Following an official request by the UK government, the General Medical Council (GMC) has granted temporary registration to 11,856 doctors who ha... more >
Matt Hancock: ‘We are more indebted than ever to NHS staff’

27/03/2020Matt Hancock: ‘We are more indebted than ever to NHS staff’

Health Secretary Matt Hancock has lauded NHS staff during his response to the healthcare service’s recently released workforce statistics, ... more >
Health Education England announce new Chief Executive

26/03/2020Health Education England announce new Chief Executive

Health Education England (HEE) have announced it will appoint Dr Navina Evans as the organisation’s new Chief Executive following a rigorou... more >

editor's comment

25/09/2017A hotbed of innovation

This edition of NHE comes hot on the heels of this year’s NHS Expo which, once again, proved to be a huge success at Manchester Central. A number of announcements were made during the event, with the health secretary naming the second wave of NHS digital pioneers, or ‘fast followers’, which follow the initial global digital e... read more >

last word

Haseeb Ahmad: ‘We all have a role to play in getting innovations quicker’

Haseeb Ahmad: ‘We all have a role to play in getting innovations quicker’

Haseeb Ahmad, president of the Association of the British Pharmaceutical Industry (ABPI), sits down with National Health Executive as part of our Last Word Q&A series. Would you talk us th... more > more last word articles >

the scalpel's daily blog

How to help patients manage the psychology of chronic conditions

20/03/2020How to help patients manage the psychology of chronic conditions

Indie Dhariwal, Wellbeing Facilitator at Living Well Taking Control Living with a chronic condition puts huge pressure on both the body and mind. Not only can it prevent patients from doing activities they used to enjoy, but in many cases, patients suffer psychological distress. Considering how difficult and disabling chronic conditi... more >
read more blog posts from 'the scalpel' >

comment

NHS England dementia director prescribes rugby for mental health and dementia patients

23/09/2019NHS England dementia director prescribes rugby for mental health and dementia patients

Reason to celebrate as NHS says watching rugby can be good for your mental health and wellbeing. As the best rugby players in the world repr... more >
Peter Kyle MP: It’s time to say thank you this Public Service Day

21/06/2019Peter Kyle MP: It’s time to say thank you this Public Service Day

Taking time to say thank you is one of the hidden pillars of a society. Being on the receiving end of some “thanks” can make communit... more >
Nurses named as least-appreciated public sector workers

13/06/2019Nurses named as least-appreciated public sector workers

Nurses have been named as the most under-appreciated public sector professionals as new research reveals how shockingly under-vauled our NHS, edu... more >
Creating the Cardigan integrated care centre

10/06/2019Creating the Cardigan integrated care centre

Peter Skitt, county director and commissioner for Ceredigion Hywel Dda University Health Board, looks ahead to the new integrated care centre bei... more >

interviews

Matt Hancock says GP recruitment is on the rise to support ‘bedrock of the NHS’

24/10/2019Matt Hancock says GP recruitment is on the rise to support ‘bedrock of the NHS’

Today, speaking at the Royal College of General Practitioners (RCGP) annual conference, Matt Hancock highlighted what he believes to be the three... more >
NHS dreams come true for Teesside domestic

17/09/2019NHS dreams come true for Teesside domestic

Over 20 years ago, a Teesside hospital cleaner put down her mop and took steps towards her midwifery dreams. Lisa Payne has been delivering ... more >
How can winter pressures be dealt with? Introduce a National Social Care Service, RCP president suggests

24/10/2018How can winter pressures be dealt with? Introduce a National Social Care Service, RCP president suggests

A dedicated national social care service could be a potential solution to surging demand burdening acute health providers over the winter months,... more >
RCP president on new Liverpool college building: ‘This will be a hub for clinicians in the north’

24/10/2018RCP president on new Liverpool college building: ‘This will be a hub for clinicians in the north’

The president of the Royal College of Physicians (RCP) has told NHE that the college’s new headquarters based in Liverpool will become a hu... more >

health service focus

View all News